I neglected to mention another mechanical fastener, namely, "V-nails." That's all I use on smaller frames. On large dimension, thick frames, these become less effective, unless you are able to seat them very deeply into the joint. This usually requires a press/driver (such as the one made by Logan). A hammer will do in a pinch, but pounding in the vicinity of close-tolerance miter joints that must remain aligned often leads to disappointment.
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