I actually think it ESSENTIAL to stand unless you have a back or knee problem that prevents it.
It's
so hard to get back from your work (sure you can do it if you make it a priority) when you sit, and it's so important in terms of assessing what you have done, and in finding mistakes to correct.
As the size of the canvas increases, the ready ability to get back also increases in importance.
If your feet, knees or back hurt at the end of the session, you just need the proper shoes