I generally employ a separate brush for every value of each color I'm painting. When I'm painting flesh for example there are many hue and intensity shifts within each value. I would use one brush for each flesh value using a rag, not thinner, to wipe off any excess paint.
If I needed to paint a larger or smaller area of the same color I'd switch to a new brush. If I were to paint something that was a different color, say blue, I would use a new brush.
At the end of the day, if I'm laying color onto a new painting, I could use thirty brushes, give or take, to cover the variety of colors and values of each. If I'm working on a specific area later in the development of the painting I could use just five or six. I never use a brush to paint two different values of the same color or two different colors of the same value.
I have nine values of grey and each of my color strings, equally stepped, between black and white paint. I mix among the two red strings, the one yellow string and the gray string at each value. Again this is a gross simplification.
I'll post a picture of my palette the next time I paint flesh.
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